Center of Rare Rheumatic and Auto-Inflammatory Diseases in Children

Center of Rare Rheumatic and Auto-Inflammatory Diseases in Children is one of the largest centers in Baltic countries. Each year 900-1000 patients are consulted, 500 of them receive inpatient services. We also provide continuous treatment with biologic and biosimilar drugs (~200 patients/year) and intraarticular injections (~200 procedures/year).

There are over 100 patients diagnosed or suspected with an auto-inflammatory disease in the Center of Rare Rheumatic and Auto-Inflammatory Diseases in Children monitoring system. Center of Rare Rheumatic and Auto-Inflammatory Diseases in Children has access to clinical, biochemical, microbiological, immunological, genetic testing, radiological diagnostics. 

Center of Rare Rheumatic and Auto-Inflammatory Diseases in Children is an affiliated member of European Reference Network on Rare Primary Immunodeficiency, Autoinflammatory and Autoimmune diseases (ERN RITA). More information about ERN RITA: http://rita.ern-net.eu/ 

Biomedical research and development is a top priority for our competence center. Specialists at the center plan epidemiologic studies of treatment results and improve treatment protocols according to evidence based medicine. Center‘s specialists participate in international conferences where they improve their knowledge and present local research results:

1. Trincianti, C., Panaviene, V. et al. Definition of new JADAS cutoffs based on subjective assessment of disease activity state by international pediatric rheumatologists, Arthritis & Rheumatology, 2020;

2. Foeldvari, I, Panaviene, V. et al Etanercept treatment for extended oligoarticular juvenile idiopatic arthritis, enthesitis-related arthritis, os psoriatic arthritis:6-year efficacy and safety data from an open-label trial. Arthritis Research and Therapy, 2019, vol. 21, p. 125 -134; 

3. Brunner H.I., Ruperto N., Panaviene V. et al.  Subcutaneous golimumab for children with active polyarticular-course juvenile idiopathic arthritis:  Results of a multicenter, double-blind, randomized-withdrawal trial. Annals of the Rheumatic Diseases. 2018, Annals of Rheumatic diseases, vol,77, p.21-29; 

4. S. Rusoniene, V. Panaviene, et al · The Lithuanian version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR) Rheumatology International (2018) 38 (Suppl 1): S275–S282;

5. Swart, J., Panaviene, V., et al. Pharmacovigilance in juvenile idiopathic arthritis patients treated with biologic or synthetic drugs: combined data of more than 15,000 patients from Pharmachild and national registries.  Arthritis Research & Therapy, 2018, vol. 20, p.285 – 295;

6. Serpytis P., Petrulioniene Z., Panaviene et al. Myocardial Infarction Associated with Kawasaki Disease in Adult Man: Case Report and Review of Literature. American Journal of Medicine, 2015, 128 (3): E1-E3;

7. Peciuliene S., ...Rusoniene S., et al.  Perinatal manifestation of mevalonate kinase deficiency and efficacy of anakinra. Pediatric Rheumatology 2016, 14:19).

The Center is actively participating in Lithuanian Rheumatologist Association activities, Paediatric Rheumatology INternational Trials Organisation (PRINTO) projects, organizes scientific conferences for students, residents, healthcare specialists and patients. Center of Rare Rheumatic and Auto-Inflammatory Diseases in Children is also cooperating with clinics and centers abroad: 

1. PRINTO and Ospedale Pediatrico Istituto Giannina Gaslini di Genova (Italy)

2. University Children's Hospital, University Medical Centre Ljubljana, Department of Allergology, Rheumatology and Clinical Immunology

3. Children's Clinical University Hospital, Vienības gat. 45, Zemgales priekšpilsēta, Rīga (Latvia)

4. Karolinska University Hospital, Registratorsfunktionen, Stockholm, Sweden

5. HUS Helsinki University Hospital, Finland

6. National Medical Academy of Post-Graduate Education Named After P.L. Shupik in Ukraine (training for pediatricians, pediatric nephrologists)

7. Corporate fund "University Medical Center" (UMC) of Nazarbayev University in Kazakhstan (aid in developing pediatric rheumatic diseases diagnostics and treatment guidelines)

1. https://klaipeda.diena.lt/naujienos/sveikata/sveikata/reumatines-ligos-neaplenkia-ir-kudikiu-776948?full

2. https://www.15min.lt/gyvenimas/naujiena/sveikata/retosios-ligos-misle-gydytojams-ir-rupestis-kudikiu-mamoms-1028-311420

3. https://www.tv3.lt/naujiena/gyvenimas/857859/issipildymo-akcijos-herojai-mantile-ir-lukas-gyvena-viltimi-nejausti-kasdienio-skausmo

4. https://www.delfi.lt/sveikata/iveik-liga/vaiko-tingumas-slepe-siaubinga-liga.d?id=71142704

5. https://www.delfi.lt/sveikata/sveikatos-naujienos/klastingos-sanariu-ligos-skauda-vienur-o-problema-visai-kitur.d?id=71500472

6. https://www.delfi.lt/sveikata/iveik-liga/vaiko-tingumas-slepe-siaubinga-liga.d?id=71142704

7. https://www.15min.lt/vardai/naujiena/lietuva/skaudantys-vaiku-gyvenimai-1050-103437

8. https://lsveikata.lt/gera-savijauta/studiju-pasirinkimas-pagal-nora-ar-sveikata-5012

9. https://www.lrytas.lt/sveikata/ligos-ir-gydymas/2020/01/26/news/benedikto-skundas-nuskambejo-kaip-pokstas-bet-paaiskejo-kad-tai-reta-liga-13360127/