The history of the Hospital is comprised of the works, which have been performed by the specialists who worked or currently work at the institution.
Vilnius University Hospital Santariškių Klinikos started its operations as the Republican Vilnius Clinical Hospital in November 1980, when the block of therapy and divisions of diagnostics started working. In 1982, the first patients were admitted to the Consultative Out-patient Department, whereas the block of surgery was opened in 1983.
The Hospital got its roots from the Republican Vilnius Red Cross Clinical Hospital and the Clinical Hospital of Vilnius City.
From the Republican Vilnius Red Cross Clinical Hospital, the Consultative Out-patient Department, run by A. Markelis, and the following In-patient Departments were moved out: Pulmonology and Allergology (Heads: late Ž. Požeraitis, R. Nargėla, prof. A. Petrauskas, prof. B. Šatkauskas), Hematology (Heads: M. Bradavičienė, late assoc. prof. J. Balsys), Gastroenterology and Dietetics (headed by P. Juodagalvytė, prof. D. Tamulevičiūtė), Abdominal Surgery (run by A. Blažys, prof. A. Bubnys, prof. A. Sviklius, assoc. prof. B. Kazlauskas), Ear, Nose and Throat Diseases (Heads: A. Burkus, assoc. prof. R. Kašinskas) and Ophthalmology (Heads: late V. adamavičienė, late assoc. prof. K. Sukarevičius, assoc. prof. G. Juodkaitė). From University Hospital of Vilnius City, the following have been moved out: a part of the Departments of Cardiology (Heads: dr. R. Vidugirienė, V. Zenkevičiūtė, prof. J. Rugienius, prof. V. Žvironaitė, late assoc. prof. A. Vidugiris), Endocrinology (run by S. Grigonis), Nephrology (Heads: N. Tylienė, doc. V. Kirsnys) and Heart Surgery, headed by the academician prof. A. Marcinkevičius, prof. V. Sirvydis, prof. G. Uždavinys, late assoc. prof. D. Kavoliūnas. The Departments of Diagnostics of Internal Diseases (Heads: D. Deniušytė, R. Stanevičienė) and Neurology (prof. P. Visockas, prof. R. Parnarauskienė, Head – A. Rauličkis) have been established.
Up to 1986, late doctor Vytautas Žygas was the first Chief Doctor of the Hospital, who run the Republican Vilnius Clinical Hospital from 1956 and actively attended to the construction of this Hospital. The buildings of the Hospital were projected by architects E. Chlomauskas, R. Plyčiuvaitis-Plyčius and Z. Liandzbergis.
Over the period from 1989 to 1996, late Juozapas Petras Radikas managed the Hospital. Under his leadership, the Hospital in 1990 became Vilnius University Santariškių Hospital, and from 1996 – Vilnius University Hospital. On the basis of then-existing departments and the departments of the Faculty of Medicine of Vilnius University, the present clinics have been formed, managed by outstanding professors and docents of Vilnius University. This period after the announcement of Lithuania’s independence and in particular during the economic blockade was a difficult one due to very poor financing of the Hospital.
Under the leadership of Director General Antanas Vinkus (1996–2002 m.), upon implementation of compulsory health insurance financing system in 1997, the Hospital became the Public Institution Vilnius University Hospital Santariškių Klinikos. In 1999, the Republican Hospital of Skin and Venereal Diseases was affiliated to VUH Santariškių Klinikos and the Clinic of Dermatovenereology was established. In the same year, the Clinic of Nephrourology was transferred from Vilnius University Antakalnio Hospital. At the initiative of A. Vinkus, the Chapel of Divine Mercy was opened in the Hospital in 2001.
Over the period from 2002 to 2013, late acad., prof. Aleksandras Laucevičius managed the Hospital.
Since 2013 has been managed by Managing Director acad., prof. Kęstutis Strupas. The development of the Hospital started, scientific activities became more extended. Projects of the European Union structural funds are being drawn up and implemented.